In the physical sciences, a partition coefficient (P) or distribution coefficient (D) is the ratio of concentrations of a compound in a mixture of two immiscible solvents at equilibrium. This ratio …

Although logP is a constant, its value is dependent on the choice of the organic partitioning solvent and, to a lesser degree, on the conditions of measurement. ACD/Labs’ logP algorithms …

Jan 6, 2024 · There is a nice theoretical relationship between LogD, LogP and pKa. The method, known as CALlogD, can be derived from the predicted LogP and pKa values (Wang et al. …

LogP is an important component of Lipinski’s Rule of 5 recommendations which predicts the drug-likeness of a new synthetic compound. According to Lipinski’s Rule of 5, an oral drug should …

Sep 3, 2022 · LogP is an important component of Lipinski’s Rule of 5 recommendations which predicts the drug-likeness of a new synthetic compound. According to Lipinski’s Rule of 5, an …

LogP describes lipophilicity for neutral compounds only, and while it can be a very useful reference point for the comparison of overall trends it should be applied with caution, …

Oct 29, 2024 · LogP and logD are important values to consider during drug design as both give insight to the lipophilicity and hydrophilicity of compounds.

Dec 14, 2022 · Drugs with a log P greater than 5 are too lipophilic (non-polar), while those with a log P less than 1 are too hydrophilic (polar). Water and 1-octanol are used as solvents in drug …

Sep 4, 2022 · LogP, a compound’s partition coefficient between an oily and aqueous phase, is used to predict absorption and is pKa-dependent. How do you calculate the LogP of a molecule?

Due to the importance of the drug lipophilicity, logP is a component of the Lipinski rule of five. 1 LogP is defined as the partition coefficient of a molecule between aqueous and lipophilic …