Mar 12, 2018 · We compared cardiovascular outcomes associated with febuxostat, a nonpurine xanthine oxidase inhibitor, with those associated with allopurinol, a purine base analogue xanthine oxidase inhibitor,...

Nov 28, 2020 · Febuxostat is non-inferior to allopurinol therapy with respect to the primary cardiovascular endpoint, and its long-term use is not associated with an increased risk of death or serious adverse events compared with allopurinol.

Febuxostat had a better safety outcome compared with allopurinol. In this systematic review and meta‐analysis, we searched MEDLINE and Embase for articles published between March 1, 2000 and April 4, 2021, without any language restrictions.

Feb 3, 2022 · This multicenter, randomized, double-blind, noninferiority trial was designed to examine the comparative efficacy and safety of allopurinol and febuxostat when appropriately titrated in...

Febuxostat is potentially more effective than allopurinol for treating patients with chronic HF and hyperuricemia. This study was registered in the University Hospital Medical Information Network Clinical Trials Registry (https://www.umin.ac.jp/ctr/; ID: 000009817).

Adjudicated cardiovascular event rates were 0% for febuxostat 40 mg, 0.4% for febuxostat 80 mg, and 0.4% for allopurinol (P=0.41 for allopurinol vs. febuxostat). No CV deaths occurred in either of the febuxostat groups, with 2 CV deaths in the allopurinol group.

Compared with allopurinol, febuxostat was associated with an improved safety outcome of cardiac-related mortality and adverse skin reactions (OR: 0.72, 95% CI: 0.55-0.96, P = 0.02).

Jan 31, 2020 · The infographic displays results proving febuxostat is more effective vs allopurinol for treating gout. The caveat is its higher risk of heart problems.

The results of a major European study have shown that a newer, long-term treatment to prevent gout attacks by lowering uric acid in the blood, is as safe in gout patients with heart and circulatory (cardiovascular) problems as the older, standard treatment.

Jan 7, 2022 · Allopurinol isn’t safe for you: If you experienced a severe allergic reaction with allopurinol, then febuxostat is a potential option to try instead. Some people — like those of Southeast Asian or African American descent — might …