Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene. [5][6] The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [7]

Mar 30, 2025 · SIN3A (SIN3 Transcription Regulator Family Member A) is a Protein Coding gene. Diseases associated with SIN3A include Witteveen-Kolk Syndrome and Chromosome 15Q24 Deletion Syndrome. Among its related pathways are Transcriptional Regulation by MECP2 and MITF-M-dependent gene expression.

On this page sin3A cos3A tan3A formulas we are going to see the formulas in trigonometry.These are the formulas that we are using in trigonometry to simplify. Here you can find example problems to show the purpose of these formulas. Sin 3A = 3 Sin A - 4 sin ³ A; Cos 3A = 4 Cos ³ A - 3 Cos A ; tan 3A = (3 tan A - tan ³ A)/(1-3tan ²A)

Suppressor interacting 3a (Sin3a) is a scaffold component of the chromatin repressive complex Sin3/histone deacetylase (Hdac). Sin3a has been shown as a hub gene driving preimplantation development in both mice and humans. However, its precise ...

Feb 9, 2025 · Results reveal a prominent role for transcriptional regulator SIN3A (SIN3A) in the transcriptional response to hypoxia, and suggesting a model where modulation of the associated histone deacetylase 1/2 activity, rather than its recruitment, determines the transcriptional output.

SIN3A-related syndrome happens when there are changes to the SIN3A gene. These changes can keep the gene from working as it should. The SIN3A gene plays a key role in controlling other genes, especially in a region of the brain called the cerebral cortex.

The Sin3a/HDAC co-repressor complex is a critical regulator of transcription networks that govern cell cycle control and apoptosis throughout development. Previous studies have identified Sin3a as essential for embryonic development around the time ...

SIN3A-related intellectual disability syndrome is caused by genetic mutations, also known as pathogenic variants. Genetic mutations can be hereditary, when parents pass them down to their children, or they may occur randomly when cells are dividing.

In this review, we delineate the SIN3a-associated epigenetic mechanisms in cancer and PAH cells and highlight their impact on cell survival and proliferation. Furthermore, we explore in detail the role of SIN3a in cancer to provide new insights into its emerging role in PAH pathogenesis.

Jul 15, 2022 · Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. Nature Genet. 48: 877-887, 2016.