NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)].

SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an instrumental regulator of the mitochondrial adaptive responses ...

Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism of multiple organs.

Mar 30, 2025 · SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and …

SIRT3 regulates intra and extra-mitochondrial proteins to maintain cell function. SIRT3 activity is central to mitochondrial and cellular homeostasis throughout the life of an organism. Stimulating SIRT3 activity can delay the progression of cellular hallmarks of aging and hinder the development of age-associated diseases.

Sep 13, 2021 · Sirt3 knockout mice were susceptible to hyper-acetylated mitochondrial proteins and to severe renal fibrosis. The activation of SIRT3 by honokiol ameliorated acetylation and prevented renal...

Feb 1, 2025 · SIRT3 protects against myocardial hypertrophy, heart failure, cardiac insufficiency. SRT3 impact neurodegenerative diseases by providing sufficient ATP to the brain. Sirtuin-3 (SIRT3) in mitochondria has nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase activity.

Jun 1, 2023 · SIRT3, a major deacetylase in mitochondria, regulates almost every aspect of mitochondrial health and functionality. SIRT3 controls vital functions like energy balance, redox status, mitochondrial quality, biogenesis, dynamics, and mitophagy.

May 15, 2012 · SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in energy metabolism processes, including the respiratory chain, tricarboxylic acid cycle, fatty acid β-oxidation and …

Feb 6, 2014 · Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, may target mitochondrial proteins for lysine deacetylation and also regulate cellular functions.