Ras-related protein Rab-18 is a protein that in humans is encoded by the RAB18 gene. [5] [6] It is a member of the Rab family of Ras-related small GTPases. [7] Rab18 is a ubiquitously expressed protein with particularly high expression in the brain. [8] Rab18 was first characterised as an endosomal protein in epithelial cells of mouse kidney ...

Mar 30, 2025 · RAB18 (RAB18, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB18 include Warburg Micro Syndrome 3 and Warburg Micro Syndrome 1 . Among its related pathways are Innate Immune System and …

Jan 4, 2018 · RAB18 deficiency is the molecular deficit underlying both Warburg micro syndrome (characterized by eye, nervous system, and endocrine abnormalities) and Martsolf syndrome (characterized by similar – but milder – findings).

Rab18 is one of the small number of conserved Rab proteins which have been traced to the last eukaryotic common ancestor. It is found in organisms ranging from humans to trypanosomes, and localizes to multiple organelles, including most notably endoplasmic reticulum and lipid droplets.

Mar 5, 2018 · Rab18 deficiency resulted in a drastically reduced number of mature LDs and decreased lipid storage, and was accompanied by increased ER stress. Rab3GAP1/2, the GEF of Rab18, promoted LD growth by activating and targeting Rab18 to LDs.

RAB18 regulates the movement of substances between compartments in cells and the storage and release of fats (lipids) by structures called lipid droplets. The protein also appears to play a role in a process called autophagy, which helps clear unneeded materials from cells.

Feb 9, 2025 · Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum. Rab18 plays a role upstream of the cytosolic lipolytic enzyme adipose triglyceride lipase (ATGL) and that recruitment of ATGL by Rab18 is mediated by elements of the Arf/GBF1 machinery.

Dec 10, 2024 · Herein, we demonstrate RAB18 knockout/knockdown efficaciously enhances siRNA-mediated gene silencing in hepatic and extrahepatic cell lines and in vivo. Our results reveal a mechanism by which retrograde Golgi-endoplasmic reticulum (ER) transport and the intracellular lipid droplets (LDs) positively regulate siRNA-mediated gene silencing.

Dec 10, 2024 · Clinical resource with information about RAB18, Warburg micro syndrome 3, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

RAB18 contains totally conserved phosphate/Mg (2+)-binding motifs and guanine-binding motifs as well as somewhat variable organelle-targeting regions. Northern blot analysis detected 2.5- and 1.0-kb transcripts in endothelial cells but not in smooth muscle cells or leukocytes.