Prophet 21 is a comprehensive enterprise resource planning (ERP) software designed for distributors to streamline operations and improve efficiency.

p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions …

One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21 …

In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have …

In this review, we focus on two important cell cycle regulators - the cyclin-dependent kinase (CDK) inhibitors p21 (CDKN1A) and p27 (CDKN1B) - by discussing their early discovery as …

We propose strategies to use p21 for intervening in cellular senescence by delaying aging, eliminating senescent cells, and rejuvenating them. Understanding the pathogenesis of p21 …

Jun 1, 2016 · The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. …

Jan 1, 2017 · Cell cycle–inhibitory function of p21. The p21 gene is a transcriptional target for multiple proliferation-inhibitory signaling cascades, including p53 (which can be activated in …

Mar 6, 2017 · Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to transient expression of the cyclin-dependent kinase inhibitor (CKI) p21. This either …

Jul 3, 2019 · Hsu and colleagues elegantly demonstrated in vitro that initial expression of p21 after chemotherapy exposure controls downstream cell fate after DNA damage induced by 1 …