Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system.

Jun 1, 2005 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and NFAT4 might also control...

The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT ...

Apr 19, 2002 · The four genes encoding the cytoplasmic subunits of NFAT transcription complexes play critical roles in regulating the genes necessary for interactions with cells that do not have antigen receptors. By this means, NFAT signaling conveys the specificity of the T cell receptor to other cell types involved in the immune response.

Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. …

Aug 20, 2010 · Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells.

Nov 3, 2022 · As a transcriptional activator widely expressed in various tissues, nuclear factor of activated T cells (NFAT) is involved in the regulation of the immune system, the development of the heart and brain systems, and classically mediating pathological processes such as …

This review discusses recent data on the diversity of the NFAT family of transcription factors, the regulation of NFAT proteins within cells, and the cooperation of NFAT proteins with other transcription factors to regulate the expression of inducible genes.

The NFAT (nuclear factor of activated T cells) family of transcription factors consists of four Ca2+-regulated members (NFAT1–NFAT4), which were first described in T lymphocytes. In addition to their well-documented role in T lymphocytes, where they ...

The NFAT family of transcription factors plays an established role in T cell activation. Rao and colleagues show that NFAT also controls the program of T cell exhaustion by regulating the expression of key inhibitory receptors and signaling molecules that dampen TCR signaling.