Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA.

Mar 30, 2025 · MBD2 (Methyl-CpG Binding Domain Protein 2) is a Protein Coding gene. Diseases associated with MBD2 include Klatskin's Tumor and Breast Cancer. Among its related pathways are RNA Polymerase I Promoter Opening and Signaling events mediated by HDAC Class I.

MBD2 seems to play a selective role in gene repression depending on the CpG content of the promoter region; Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line.

Jun 29, 2023 · Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of the NuRD complex. Several MBD2 and MBD3...

Jul 13, 2023 · These findings suggest that Mbd2 is a novel epigenetic regulator of genes that are associated with ASD in humans. Mbd2 loss causes behavioral alterations that resemble those found in ASD...

MBD2 aggravates pulmonary fibrosis by enhancing TGF-β/Smad signaling. MBD2 promotes Th17 cell differentiation by downregulating SOCS3 expression. MBD2 inhibits the expression of Ship, enhances the PI3K/PKB signaling pathway, and then induces pulmonary fibrosis.

MBD2 has been linked to immune system function and tumorigenesis, yet little is known about its functions in vivo. Recent studies have found the MBD2 protein is ubiquitously expressed, with relatively high levels in the lung, liver, and colon.

Dec 9, 2014 · This review focuses on two members of the methyl binding proteins, namely MBD2 and MBD3 that reside in very similar complexes, yet appear to have very different biological roles. We provide a comprehensive comparison of their genome-wide binding features and emerging roles in gene regulation.

Mar 1, 2024 · Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA.

Nov 19, 2012 · DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MBD2 specifically binds methylated DNA, colocalizes with methylated sequences, and is likely to mediate the effects of DNA methylation in mammalian cells (Hendrich and Bird, 1998).