Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene. [5] The protein encoded by this gene is a member of the E2F family of transcription factors.

Mar 28, 2025 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma. Among its related pathways are Defective binding of RB1 mutants to E2F1, (E2F2, …

E2F proteins regulate the transcription of S phase cyclins and genes required for DNA replication, DNA repair, and apoptosis. The activity of E2F1, the archetypal and most heavily studied E2F family member, is tightly controlled by the DNA damage checkpoints to modulate cell cycle progression and initiate programmed cell death, when required.

Activators such as E2F1, E2F2, E2F3a promote and help carryout the cell cycle, while repressors inhibit the cell cycle. Yet, both sets of E2F have similar domains. E2F1-6 have DP1,2 heterodimerization domain which allows them to bind to DP1 or …

E2F1 shows structural homology with other E2F activators. It has a single DNA binding domain and heterodimerizes with a dimerization partner (DP1/DP2) in order to effectively bind DNA and recruit other transcription factors and co-activators to target gene promoters.

Nov 10, 2017 · We summarize recent findings about the cell cycle-independent roles of E2F1 in various tissues that contribute to global metabolic homeostasis and highlight that E2F1 activity is increased during obesity.

May 3, 2019 · This study shows that minor copy number changes (one to two extra copies) of E2f1 or E2f3b are sufficient to induce liver cancer in mice.

Apr 7, 2025 · In cultured neurons, HIV-1 gp120 increases transcription factor E2F1 levels in the nucleus, stimulates its transcriptional activity, and enhances the expression of the E2F1 target proteins Cdc2 and Puma

E2F1 has a cancer protective role in oncogenic BRAF-activated melanoma cells. E2F1 promotes the transcription of lncRNA RGMB-AS1 in papillary thyroid carcinoma (PTC). blocking E2F1 also induced death of melanoma cells resistant to BRAF inhibitors.

Dec 3, 2023 · E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway. Song L, Li H, Ma RR, Liu S, Zhang GH, Guo XY, Zhao RN, Wu XJ, Zhang K, Gao PSong L, et al .