CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family.

The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4 + T cells, CD8 + T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) and also at a high level by endothelial cells.

Mar 28, 2025 · CD9 (CD9 Molecule) is a Protein Coding gene. Diseases associated with CD9 include Cytomegalovirus Retinitis and Acquired Immunodeficiency Syndrome . Among its related pathways are Response to elevated platelet cytosolic …

Mar 30, 2020 · Here we report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2.

Apr 30, 2018 · The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4 + T cells, CD8 + T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) and also at a high level by endothelial cells.

Apr 28, 2020 · CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic responses, and viral infection. CD9...

Oct 9, 2018 · CD9 belongs to the tetraspanin superfamily. Depending on the cell type and associated molecules, CD9 has a wide variety of biological activities such as cell adhesion, motility, metastasis, growth, signal transduction, differentiation, and sperm-egg fusion.

Feb 8, 2025 · CD9, a potential leukemia stem cell marker, regulates drug resistance and leukemia development in acute myeloid leukemia. Genetic Predisposition to Colon and Rectal Adenocarcinoma Is Mediated by a Super-enhancer Polymorphism Coactivating …

Mar 15, 2022 · Also called tetraspanin CD9, motility related protein 1 (MRP1) [note: MRP is multidrug resistance associated protein] Antibodies are used to purge bone marrow in acute lymphoblastic leukemia prior to peripheral stem cell bone marrow transplant ( Am J Pediatr Hematol Oncol 1993;15:162 )

CD9 is a protein that is involved in cell signaling and adhesion. It is found on the surface of various cells, including cancer cells, and has been implicated in the communication between cancer cells and their microenvironment.