CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. [5] [6] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

Dec 24, 2024 · CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Calmodulin induced events.

CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans.

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-kappaB pathways. cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1. Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population.

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription …

Apr 28, 2020 · Cyclic AMP (cAMP)-response element-binding protein 1 (CREB) is a 43 kDa stimulus-induced transcription factor (TF). It can bind to the cAMP response element (CRE) sequence TGACGTCA or the conserved half CRE TGACG and was first identified in the somatostatin gene promoter [1].

Development of effective HIV-1 vaccines requires synergy between innate and adaptive immune cells. We show that induction of the transcription factor CREB1 and its target genes by the recombinant canarypox vector ALVAC+Alum augments immunogenicity ...

Nov 14, 2024 · Title: CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma. Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.

Feb 5, 2024 · Clinical resource with information about CREB1, Angiomatoid fibrous histiocytoma, Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens., and available tests.

The CREB1 gene encodes three functional isoforms of CREB α (also known as isoform B), Δ (isoform A) and β (isoform C) produced by alternative splicing. CREB Δ is ubiquitously expressed in adult tissues and is the most abundant isoform in normal adult tissues, comprising approximately 60–70% of the total CREB in a tissue .