CD5 includes a scavenger receptor cysteine-rich protein domain. T cells express higher levels of CD5 than B cells. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides.

Jan 30, 2025 · CD5 is typically expressed in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), thereby distinguishing these disorders from other small chronic B cell lymphoproliferative disorders (Med Sci Monit 2017;23:2137)

May 25, 2023 · It had been clear, that the antiquated T cell marker CD5 is important for T cell receptor signaling fine tuning and for protection from activation-induced cell death. 2 Historically, CD5 has...

Mar 28, 2025 · CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include Thymic Carcinoma and Prolymphocytic Leukemia. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers …

CD5 is a molecule involved in signal transduction through tyrosine phosphorylation of intracellular proteins. It plays a role in modulating signaling via antigen-specific receptor complexes in T and B lymphocytes, with high expression on mature T-lymphocytes and low expression on a subset of mature B-lymphocytes.

CD5 is a protein normally found on the surface of specific immune cells, particularly certain types of lymphocytes (a kind of white blood cell). CD5 helps these immune cells communicate and interact within the immune system, especially in regulating immune responses and preventing autoimmune reactions.

CD5 is a scavenger-like receptor expressed in association with the antigen-specific receptors on T and B-1a lymphocytes. Recent studies reveal a broader biology for CD5 that includes its role as regulator of cell death and as a receptor for pathogen ...

CD5 is a negative regulator of B-cell receptor (BCR) signaling that is up-regulated after BCR stimulation and likely contributes to B-cell tolerance in vivo. However, CD5 is constitutively expressed on the B-1 subset of B cells.

CD5 is a well established negative regulator of TCR and BCR signalling. In the last years, great advances have been made in understanding the molecular mechanisms behind this regulatory function.

Dec 7, 2018 · Here we focus on CD5, a transmembrane receptor that regulates T cell functions and development but remains poorly characterized at the molecular level. We will review its roles in physiological conditions and suggest potential molecular effectors that could account for CD5-dependent regulation of TCR signaling.