Jan 24, 2015 · By the way, the reason tetrahydrobiopterin (BH4) is so expensive, and without prescription is only available in small dose tablets, is because BH4 was given orphan drug …

May 6, 2017 · NADH is required both to make BH4 and to recycle it. Ref: 1 Folate may help increase BH4, according to Martin Pall. Ref: 1 BH4 is very sensitive to oxidation by reactive …

May 5, 2012 · There were basically two reasons for why I wanted to increase BH4. The first one has to do with oxidative/nitrosative stresses. In this case, the more BH4 you have, the less …

Apr 13, 2011 · Life Extension had an article that said 5-MTHF, in sufficient amounts, can sometimes substitute for BH4 in BH4's functions (which I believe was derived from a PubMed …

Apr 13, 2011 · I think we urgendly need more research on BH4 and its connetions. BH4 deficiency causes muscle weakness, dystonia, parkinson like symptoms, and so on. BH4 is needed to …

May 2, 2020 · Sepiapterin is a natural precursor of BH4 and is converted to BH4 intracellularly so has substantial pharmacological advantages over sapropterin that include better plasma …

Mar 23, 2013 · 2) BH4 is also a cofactor for the enzyme NOS which converts arginine to nitric oxide (NO) plus citrulline. Ammonia is not involved in this reaction. That is not the sum total of …

Mar 23, 2013 · Pharmacological doses (200 mg/day) of BH4 has been shown to be safe and effective when used to treat endothelial dysfunction in hyperlipidemic individuals, and in …

Jul 31, 2014 · Your metafolin doses are probably raising your BH4, and that is helping with your reactivity. With your MTHFR C667T and A1298C, you may be compound hetero (if so, …

Mar 23, 2013 · But all the other sources of BH4, such as Pteridin-4 from Ecological Formulas, are at low doses (eg 2.5 mg), sold as "homeopathic" formulations. However, this BH4 orphan drug …