No. 18 Michigan inflicted a pair of significant blows in the first half against No. 11 USC on Saturday, taking a 14-3 lead into the break behind stingy defense and explosiveness in its run game. Kalel Mullings busted a 53-yard touchdown run on the Wolverines' third possession to open the scoring after the teams traded early punts.

Kalel Mullings had a 2-yard, go-ahead touchdown run on fourth down with 37 seconds left, lifting No. 18 Michigan to a 27-24 win over No. 11 USC.

The early window of Week 4 featured blowouts by James Madison, Clemson, and Ohio State, while Michigan edged USC in a thrilling Big Ten opener.