C&EN1mon
Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells
By employing a proprietary linker and conjugation chemistry, we developed an ADC with a TLR7 agonist covalently linked to a mouse IgG2a antibody that targets mouse tyrosinase-related protein 1 (TRP1 ...
eLife1y
TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity
Danger signals from peripheral tissues can influence this process. Herein we demonstrate that repetitive TLR7 stimulation via the epithelial barriers drove a potent emergency bone marrow monocyte ...
Frontiers5y
TLR7 Protein Expression in Mild and Severe Lupus-Prone Models Is Regulated in a Leukocyte, Genetic, and IRAK4 Dependent Manner
Moreover, it is important to know if these suppressive effects of IRAK4 elimination on TLR7-dependent lupus-traits are due to the loss of susceptibility loci resulting from the introduction of ...