Uricase degrades relatively insoluble uric acid to the more soluble compound allantoin. Urate reabsorption by urate transporter-1 is partly suppressed at the proximal tubule lumen membrane by the ...

Objectives Human urate transporter 1 (URAT1) is a member of the organic anion transporter family (SLC22A12) that primarily regulates the renal tubular reabsorption of uric acid. This case–control ...

Dotinurad achieves this by selectively inhibiting urate transporter 1 (URAT1), a protein in the kidneys that reabsorbs uric acid. By blocking URAT1, dotinurad reduces uric acid reabsorption, ...

Introduction: Achieving a goal of serum urate levels in patients with gout is an important way to prevent gout and its complications while it remains difficult with a low targeting rate worldwidely.

Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas 77204, United States Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station ...

Objectives To evaluate the sensitivity to change of ultrasound structural gout lesions, as defined by the Outcome Measures in Rheumatology (OMERACT) ultrasound group, in patients with gout during ...

Potential associations between urate and gout and lipid-lowering drugs have been revealed in observational studies. However, the effects of lipid-lowering drugs on urate and gout remain controversial.

OBJECTIVES To study the efficacy of allopurinol and benzbromarone to reduce serum urate concentrations in patients with primary chronic gout. METHODS Prospective, parallel, open study of 86 ...

The secondary objective was to test the concurrent validity of US abnormalities using as gold standard the microscopic demonstration of monosodium urate (MSU) crystals. Methods Ninety-one men with ...

What Uric Acid Level Indicates Hyperuricemia? A uric acid level of 6.8 mg/dl or higher means you have hyperuricemia. A normal serum urate level for assigned females is 1.5 to 6.0 mg/dL. For assigned ...

These data support continued investigation of oral verinurad in patients with gout. Febuxostat is a xanthine oxidase inhibitor (XOI) used to reduce serum urate (sUA) levels in patients with gout. In ...