Medscape1mon
Genetic Variability of Surfactant Protein-B and Respiratory Distress Syndrome: Clinical Implications
Genetic Variability of Surfactant Protein-B and Respiratory Distress Syndrome: Clinical Implications. MedGenMed 1(3), 1999 [formerly published in Medscape Pulmonary Medicine eJournal 3(2), 1999].
BMJ2y
Genetic disorders of surfactant protein dysfunction: when to consider and how to investigate
The genes involved in these disorders code for pulmonary surfactant production and include surfactant protein B (SP-B) (SFTPB, gene encoding SP-B), surfactant protein C (SP-C) (SFTPC, gene encoding SP ...
thorax.bmj1mon
Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis
a Royal Brompton Hospital and Imperial College School of Medicine at the National Heart & Lung Institute, London SW3 6NP, UK, b MRC Immunochemistry Unit ... The presence of an antagonist for the ...
New surfactant could improve lung treatments for premature babies
Scientists have developed a new lung surfactant that is produced synthetically rather than relying on the use of animal ...
BMJ18d
Outcome following pulmonary haemorrhage in very low birthweight neonates treated with surfactant
AIM To determine if pulmonary haemorrhage after surfactant treatment increases short and long term morbidity and mortality in neonates weighing <1500 g at birth. METHODS Neonates weighing <1500 g at ...
Frontiers3y
Gene Therapy Potential for Genetic Disorders of Surfactant Dysfunction
Schematic of SP-B, SP-C, and ABCA3 protein localization in an alveolar type II cell. 1) ABCA3 transports phospholipids into lamellar bodies; SP-B and SP-C provide support during surfactant assembly ..
cirm.ca.gov5mon
A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response.
Sandra L Leibel, Rachael N McVicar, Rabi Murad, Elizabeth M Kwong, Alex E Clark, Asuka Alvarado, Bethany A Grimmig, Ruslan Nuryyev, Randee E Young, Jamie C Lee, Weiqi Peng, Yanfang P Zhu, Eric Griffis ...
casereports.bmj3y
Surfactant dysfunction disorder masquerading as meconium aspiration syndrome and persistent pulmonary hypertension of the newborn
We report a case of surfactant dysfunction ... diffuse developmental lung diseases especially surfactant dysfunction syndromes. Exome sequencing detected a heterozygous missense variation in exon 21 ...
BMJ2mon
The potential of recombinant surfactant protein D therapy to reduce inflammation in neonatal chronic lung disease, cystic fibrosis, and emphysema
howard.clarkbioch.ox.ac.uk By lowering surface tension at the air-water interface in the surfactant deficient premature lung, exogenous surfactant replacement therapy for neonatal respiratory distress ...
oem.bmj2mon
Lung hyperpermeability and asthma prevalence in schoolchildren: unexpected associations with the attendance at indoor chlorinated swimming pools
Methods: In 226 healthy children, serum surfactant associated proteins A and B (SP-A and SP-B), 16 kDa Clara cell protein (CC16), and IgE were measured. Lung specific proteins were measured in the ...
casereports.bmj6mon
Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings
along with Krebs von den Lungen-6 and surfactant protein-D assessment, is necessary for the prevention of extensive pneumonitis. If possible, histology from lung biopsy also helps to improve treatment ...