Researchers reveal that spermidine-mediated acetylhypusination of RIPK1 suppresses necroptosis and insulin resistance, ...

Panbela Therapeutics, Inc. (OTCQB: PBLA), a clinical stage company developing disruptive therapeutics for the treatment of patients with urgent unmet medical ...

Panbela Therapeutics, Inc. ( (PBLA) ) has released its Q3 earnings. Here is a breakdown of the information Panbela Therapeutics, Inc. presented ...

Our lead assets ivospemin, eflornithine, and Flynpovi target the polyamine pathway in ways that could complement ImmunityBio's natural killer cell and killer T cell activation technology. The ...

Notes payable, plus accrued interest, totaled approximately $6.9 million. The current portion of the notes payable plus accrued interest totaled approximately $3.7 million. Included in the current ...

Researchers found that caffeine blocks alcohol’s ability to increase dopamine in brain reward areas, potentially reducing ...

Recent research reveals that the immune system interacts with the body's internal clock, influencing both fat storage and ...

As an outcome, several drugs, such as Metformin, Itraconazole, Pimozide, and Disulfiram, were repurposed to regulate metabolic and EMT pathways. Moreover, strategies such as combination therapy, ...

In mammals, pyruvate is the primary substrate for lactate production. It plays a critical role in metabolism by linking glycolysis, where it is produced, with the mitochondrial oxidative ...

On the other hand, the presence of vitamins and minerals in the body not only modulates metabolic processes and signaling pathways but also affects significantly the composition and function of the ...

These genes are responsible for transcribing antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX), via the mitogen-activated protein kinases (MAPKs) ...