Myocardial remodeling is a key pathophysiological basis of heart failure, which seriously threatens human health and causes a severe economic burden worldwide. During chronic stress, the heart ...
An improved understanding of the mechanisms driving vascular smooth muscle cell (VSMC) modulation in the diseased vessel wall is needed to improve our approach to atherosclerotic plaque cap ...
Figure 3. LIMK activity promotes VSMC migration. The activation of RhoA/ROCK by stimuli such as PDFG-BB leads to the phosphorylation of LIMK and inactivation of cofilin, thereby promoting actin ...
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