In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...

Ubiquitylation, a post-translational modification, has been implicated in the regulation of VSMC phenotype switch ... platelet-derived growth factor-BB (PDGF-BB)-induced proliferation, phenotype ...

PDGF and its receptors are implicated in tumorigenesis and angiogenesis, prompting Sebti and colleagues to design a synthetic molecule, called GFB-111, that binds to PDGF. Their new molecule has ...