Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components of the internal immune cells, which profoundly affects the internal ...

Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, P. R. China Key Laboratory of Advanced Technologies of Materials Ministry of Education, School ...

There is solid evidence for the cleavage of VgrG2B by Caspase 11 and the generation of fragments that inhibit activity of the NLRP3 inflammasome. This work should be of interest to immunologists and ...

PharmaCenter Bonn & Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany Collaborative Research Center (CRC/SFB 1328), Department ...

Nomination of NLRP3 inhibitor BGE-102 as a development candidate, with initial Ph1 clinical data anticipated by end of 2025 Expansion of discovery efforts based on insights from BioAge’s platform, ...

Alternatively, NLRP3 can sense either the efflux of K+ or the loss of membrane integrity. 2): Crystalline or particulate agonists can be phagocytosed, resulting in the release of lysosomal cathepsins ...

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by ...

The isolated cargo is then degraded in the autolysosome which is formed via autophagosome-lysosome fusion. Figure 2. Autophagy and the inflammasome. TLR signaling results in the activation of NF-κB ...