This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Oscillatory p53 expression occurs in ...

Sequences are ordered lists of objects that follow specific patterns or rules. Each number in the sequence is called a term. Sequences can be classified as arithmetic or geometric. Arithmetic ...

MDM2 siRNA (GenePharma, Shanghai, China) was utilized to suppress the expression of MDM2.The Si-MDM2 sequence is: 5′- CAG GCA AAT GTG CAA TAC CAA CA -3′. Cells were inoculated into 6-well plates at a ...

The network tests for Elden Ring Nightreign have already come and gone, which only means one thing - we're closer than ever to finally getting our hands on some co-op soulslike goodness.

Now with MAGMA, if developers want to build agents that execute both physical or user interface/browser tasks, that same assistant would call upon Magma to understand the environment, perform ...

These proteins, called MDM2 and MDMX, become overactive in cancer and break down p53. Researchers have developed drugs to block MDM2 or MDMX, but targeting just one of these proteins is often not ...

Navtemadlin is an MDM2 inhibitor that can help to kill cancer cells by boosting the activity of p53, a protein that controls cell growth and induces cell death in response to DNA damage.

Investopedia / Yurle Villegas The Fibonacci sequence is a series of numbers where each successive number is equal to the sum of the two numbers that precede it. The Fibonacci sequence is one of ...