Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing ...

Objective Sustained inflammation originating from macrophages is a driving force of fibrosis progression ... and serves as a connecting metabolic hub between endocannabinoid and lipid signalling ...

These observations indicate that PPAR-γ may have an important role in macrophage differentiation as well as in macrophage lipid metabolism ... were washed in M2 medium (Specialty Media ...

BPH macrophages do not distinctly categorize into M1 and M2 phenotypes. Instead ... Specifically, macrophage subpopulations with altered lipid metabolism pathways, demarcated by TREM2 and MARCO ...

The study, led by Prof. Charlotte Scott and her team, was published in Immunity and identifies a key role for lipid-associated macrophages (LAMs) and LAM-like Kupffer cells (KCs) in promoting recovery ...

We show that Wag31 predominantly interacts with several membrane-associated proteins involved in lipid metabolism, cell wall synthesis and division. Native levels of Wag31 are critical for the ...

Division of Physiological Chemistry and Metabolism, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-0011, Japan Laboratory of Metabolomics, RIKEN Center for Integrative ...

Therefore, we assume the combination of anti-PD-1 therapy towards malignant tumors with targeting lipid metabolism of TAMs might selectively strike M2-like macrophages without impairing M1-like ...

This study uses a wide range of approaches to identify acylation as a key regulator of Orai1 channel activation and calcium entry. The results show a novel role for Orai1 acylation in promoting ...

LKB1 and lipid metabolism reprogramming of macrophages in atherosclerosis ... M1, classically activated macrophage; M2, alternatively activated macrophage; IL, interleukin; TNF, tumor necrosis factor; ...