These observations indicate that PPAR-γ may have an important role in macrophage differentiation as well as in macrophage lipid metabolism ... were washed in M2 medium (Specialty Media ...

BPH macrophages do not distinctly categorize into M1 and M2 phenotypes. Instead ... Specifically, macrophage subpopulations with altered lipid metabolism pathways, demarcated by TREM2 and MARCO ...

Understanding why newborns, but not adults, can regenerate the heart could lead to treatments that "reprogram" adult ...

Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.

The concept of using vaccines to treat cancers has been around for several decades. A vaccine was first approved for prostate cancer in 2010, and another was approved in 2015 for melanoma. Since then, ...

Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing ...

The study, led by Prof. Charlotte Scott and her team, was published in Immunity and identifies a key role for lipid-associated macrophages (LAMs) and LAM-like Kupffer cells (KCs) in promoting recovery ...

It is a goal to achieve targeted delivery to a specific cell population (e.g., TAMs), and even a specific phenotype of a cell group (e.g., M2-like TAMs) in the TME. With the advance of ...

Conversely, inhibiting of PPARγ suppresses M2 macrophages and increases the proportion of M1 macrophages (34). He et al. conducted a comprehensive analysis of dynamic changes in cell signaling and ...

The work will be of interest to cell biologists and biochemists working in metabolism ... by boosting M2 population which then synthesize and secrete catecholamines to promote thermogenesis. It is now ...

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