ALZFORUM9d
After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods
Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...
Frontiers18d
Neuronopathic Gaucher disease: Beyond lysosomal dysfunction
β-GC hydrolyzes glucosylceramide (GluCer) into glucose and ceramide in the lysosome, and the loss of its activity leads to GluCer accumulation in different tissues. In severe cases, enzymatic ...
C&EN22d
Lysosome-Targeting Chimera Using Mannose-6-Phosphate Glycans Derived from Glyco-Engineered Yeast
Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, ...
The EMBO Journal23d
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. As a common and severe cerebrovascular disease ...
eLife24d
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis
We also investigated the effect of U18666A on CF555-dextran endocytosis. By examining the localization of CF-dex and Lamp1, we found that CF555 is present in the lysosome with U18666A treatment (Fig ...
Frontiers28d
Lysosome targeted therapies in hematological malignancies
This figure highlights lysosomes’ dual role in promoting both cellular survival through autophagy and inducing cell death when lysosomal integrity is disrupted. Key components of the lysosomal ...