Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

The cell NAD+/NADH ratio can constrain biomass synthesis and influence proliferation in nutrient-limited environments. However, which cell processes regulate the NAD+/NADH ratio is not known. Here, we ...

The reaction progress and increase in molecular weight was monitored through gel permeation chromatography (GPC) measurements (cf. Table S1). The reaction proceeded, until a high molecular weight ...

It was stable at 25 °C with a half-life of 323 h in an aqueous solution. Ps Hep-III was employed for the depolymerization of heparin, and the enzymatic hydrolyzed products were analyzed with gel ...