Cells navigating in complex microenvironments frequently encounter narrow spaces that physically challenge migration.

Introduction: Dendritic cells (DCs) play a crucial role in orchestrating immune responses by bridging innate and adaptive immunity. In vitro generation of DCs from mouse and human tissues such as bone ...

Using Apc min/+ mice, a mouse model for intestinal ... induction of small intestinal T cells by food antigens. On the follicle-associated epithelium (FAE) of PPs, microfold (M) cells pass food ...

Our mission is to provide a state-of-the-art facility, expertise, and education in advanced quantitative light microscopy to support Drexel University’s research community The Cell Imaging Center (CIC ...

Mechanistically, CCR4 deficiency in Tregs impaired their suppressive function and migration to the atherosclerotic aorta and augmented Th1 cell-mediated immune responses through defective regulation ...

1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 2Department of Surgery, Keio ...

Although most conditions can be diagnosed by light microscopy, immunohistochemistry has several specific uses in non-neoplastic lung diseases. For the diagnosis of Langerhans' cell histiocytosis ...

FTO plays an oncogenic or tumour-suppressive role in different cancers. FTO inhibition has been reported to sensitise leukaemic cells to T cell cytotoxicity and overcome hypomethylating agent-induced ...

Immunofluorescence and immunohistochemistry are performed to detect the presence of immune cells on paraffin-embedded and formalin-fixed samples. The underlying regulatory mechanisms of metabolic ...