Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...

The finding that reduced CUL5 gene activity increases CAR-T cell anticancer effects could improve treatment for patients with aggressive cancers such as leukemia, lymphoma, and multiple myeloma.

Overexpression of epitope-tagged versions of Vwa1, Vwa2, and FbxwD was accomplished essentially as described (Sheikh et al., 2015). Strains are listed in Table 1. The entire ORF of Vwa1 was amplified ...

A prominent obstacle to HIV eradication in seropositive individuals is the viral persistence in latent reservoir cells, which constitute an HIV sanctuary out of reach of highly active antiretroviral ...