Temperature-sensitive protein module can guide cell activity remotely
Imagine being at a big marquee event in an arena, like the Super Bowl, with the roar of the crowd, the smell of hot dogs, and ...
eLife2d
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...
The EMBO Journal22d
TRIM32 regulates insulin sensitivity by controlling insulin receptor degradation in the liver
High-fat diet induces SREBP-1c-dependent expression of the E3 ubiquitin ligase TRIM32. TRIM32 impairs cellular insulin action by degrading cell surface insulin receptors in the liver. Hepatic ...
eLife23d
Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function
This important work identifies a non-autophagic role for ATG5 in lysosomal repair and the trafficking of the glucose transporter GLUT1 to the cell surface, mediated through the retromer complex. The ...
Medical News Today26d
Cells all over the body store 'memories': What does this mean for health?
Share on Pinterest Do all our cells have a type of memory, and if so, how might this influence health? We investigate. Design by MNT; Photography by Grant Faint/Getty Images & Ed Reschke/Getty Images.
C&EN1mon
Ligand-Mediated Surface Reaction for Achieving Pure 2D Phase Passivation in High-Efficiency Perovskite Solar Cells
Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University Fuzhou, Fuzhou 350207, China Department of Chemical and Biomolecular Engineering, ...