The histological diagnosis was lymphocytic hypophysitis. Immunostains were positive for CD3 and CD20. Immunostains for acid-fast bacilli, PLAP and OCT3/4 were negative. The patient remains ...

Explore how T cell engagers could transform cancer and autoimmune treatments through promising trials and key collaborations.

establishing itself to the new standard of care and it's also an opportunity to further build upon it with combinations with the CD20/CD3 bispecifics that we have. Hemlibra patient share in the U ...

which targets CD20 and CD3 receptors on cells, and combination therapies. The deal is back-ended with $1.18 billion in potential milestones, plus royalties, and also covers a series of bispecifics ...

The large atypical cells are positive for EMA and CD5 and appear to be negative for CD15, CD3, CD2, CD20, PAX5, and BCL2. ALK staining highlights a large subset of atypical large cells. 51-year-old ...

The trial showed that the double-headed antibody – which targets CD3 on white blood cells and CD20 on tumour cells – was tolerable and showed evidence of clinical activity in diffuse large B ...

Regeneron Pharmaceuticals, Inc. REGN reported fourth-quarter 2024 earnings per share (EPS) of $12.07, which beat the Zacks Consensus Estimate of $11.62. The company recorded an EPS of $11.86 in the ...

Briefly, cells were incubated on ice with monoclonal antibodies to CD11b and CD20 (for the depletion of ... More than 95% of the cells collected were CD3 +. Purified T cells were cultured for ...

Tumors with high pTLS density showed significantly increased expression of Th1-, Th17- and immune suppression-related genes, as well as significantly higher infiltration of CD3+, CD8+ and CD20+ cells ...

Background: Immunohistochemistry (IHC) is a widely used laboratory technique for cancer diagnosis, which selectively binds specific antibodies to target proteins in tissue samples and then makes the ...

Colon, kidney and gallbladder tissue specimens were stained for CD19, CD20, CD3 and CD68 scanned, and annotated by pathologists (ME and JV) as described above. Cells were also automatically quantified ...