Nature5d
Mechanisms of change in gene copy number
Programmed two-ended DSBs occur in the immune system, and their repair might relate to the formation of some translocations seen in patients with leukaemia (reviewed in Ref. 76). Programmed two ...
Nature5d
Breaking the chains: structure and function of the deubiquitinases
These include USP1, which undergoes inactivating auto-proteolysis 46, and A20, which is proteolytically inactivated by mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1 ...
Frontiers5d
Advances in the role of STAT3 in macrophage polarization
Figure 2 Diagram of signaling pathways related to STAT3 and macrophage ... which regulates gene transcription by affecting the phosphorylation and nuclear translocation of STAT3, have effects on ...
Frontiers5d
Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units
The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...
jmg.bmj5d
Long-read sequencing for detection and subtyping of Prader-Willi and Angelman syndromes
Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are imprinting disorders caused by genetic or epigenetic aberrations of 15q11.2-q13. Their clinical testing is often multitiered; diagnostic ...