EurekAlert!23d
Acupuncture protects brain regions in an Alzheimer’s disease mouse model by inhibiting apoptosis and reducing tau protein
Acupuncture treatment on the DU channel has shown therapeutic effects for Alzheimer’s disease (AD), but the underlying mechanisms are not yet clear. The purpose of this study was to comprehensively ...
The EMBO Journal9d
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...
Nature9d
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Apoptosis and autophagy constitute the two ... recruitment to autophagosomes provides a shift from diffuse to punctate staining of the protein and increases its electrophoretic mobility on gels ...
Nature11d
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
Resistance to apoptosis, therefore ... 4 μm in thickness and stained with hematoxylin and eosin. For TUNEL staining, the tumors were either untreated or treated intratumorally with TNFα for ...
Artemisia herba-alba: Scientists Have Discovered That a Common Herb Could Help Treat Colon Cancer
Researchers have found that Artemisia herba-alba, a medicinal herb, contains compounds capable of fighting colorectal cancer.
gut.bmj5d
Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors
TUNEL staining indicated that loss of activated HSC resulted from an increase in the rate of apoptosis during the first two days post biliodigestive anastomosis. Serum deprivation and culture in the ...
ahajournals.org15d
Abstract TMP5: The Impact of Enteral Nimodipine on Endothelial Cell Apoptosis in an Animal Subarachnoid Hemorrhage Model
The effects of enteral nimodipine were analyzed by group using histopathologic analysis, including immunohistochemical staining of apoptosis-related proteins (Bcl2 [anti-apoptotic] and Bax ...
Frontiers11d
Effect of Celastrus Orbiculatus Extract on proliferation and apoptosis of human Burkitt lymphoma cells
We also conducted Annexin V-PI and JC-1 staining experiments to assess apoptosis. By combining the cell cycle experiment with the EDU assay, we gained insights into the effects of COE on DNA ...
Frontiers11d
The GDF11 Promotes Nerve Regeneration After Sciatic Nerve Injury in Adult Rats by Promoting Axon Growth and Inhibiting Neuronal Apoptosis
C), which was consistent with the HE staining results. These findings indicate that GDF11 promotes the growth of nerve fibers. Our study demonstrated that GDF11 can inhibit DRG cell apoptosis and ...
eLife29d
Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during early development
The apoptosis of motor neurons occurred quickly and almost at ... The motor neurons of the sensor zebrafish were identified by immunofluorescence staining using an anti-GFP antibody plus a secondary ...
bjo.bmj11d
Network pharmacology and biochemical experiments reveal the antiapoptotic mechanism of huperzine A for treating diabetic retinopathy
H&E staining, optical coherence tomography ... huperzine A may treat diabetic retinopathy via key target HSP27 and apoptosis-related pathways. Huperzine A may modulate the phosphorylation of HSP27 and ...
gut.bmj11d
Cabozantinib-based combination therapy for the treatment of hepatocellular carcinoma
21 Using Sirius Red staining as well as immunostaining with anti-Vimentin ... As cabozantinib induces HCC cell apoptosis, it is possible that cabozantinib treatment triggers the release of liver ...