Small HDL particles play a significant role in the prevention of Alzheimer’s disease, and an inherited gene present in one in four people hinders its production in the brain, increasing risk for ...

"It seems that the HDL-like particles containing APOE2 or APOE3 are larger and are more effective at transferring the lipids and cholesterol linked to them relative to APOE4-containing particles ...

More information: Shaowei Wang et al, Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD, Molecular Neurodegeneration (2025). DOI: 10.1186 ...

If you have two copies of the APOE4 gene, new research suggests that you’re very likely to develop Alzheimer’s. Experts break down the findings and share what you can do to lower your risk.

Classifying APOE4 as an inherited form of the disease has some big implications. First, it would mean that a far greater proportion of Alzheimer’s cases are caused by genes than has been ...

APOE4 is the strongest risk factor for late-onset Alzheimer's, the most common form of the disease that develops after the age of 65, according to the National Institutes of Health. The disease ...

But APOE4 is one of the clearest genetic links to Alzheimer’s, with one copy increasing the risk by up to three times, and two copies boosting that risk to 10 times.

A study has found that having two APOE4 genes may not just be a risk factor in Alzheimer's disease, but a driver of it. Nearly all carriers' brains showed key disease biomarkers by age 65 ...

Summary. Non-APOE4 carriers do not benefit from treatment with lecanemab. Lecanemab reduces the rate of progression of APOE4 carriers closer to that of non-carriers in mild Alzheimer's disease.

People with two copies of the gene variant APOE4 are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such patients could be diagnosed years before symptoms.

Classifying APOE4 as an inherited form of the disease has some big implications. First, it would mean that a far greater proportion of Alzheimer’s cases are caused by genes than has been ...