For example, antifungal agents are often ... namely reduction in the concentration of the drug target—thus eliminating it as a site of action; changes in molecule biosynthesis; and pumps that ...

This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing ...

"For decades, clinicians have relied on a handful of antifungal classes, with few mechanisms of action and significant limitations due to spectrum of activity, drug toxicities, or drug-drug ...

The experience and recommendations of combinational antifungal therapy for ... stated Poorly mimics human disease, the action and side effects of test drug in vivo may not imitate that in human ...

Without immediate action, humanity will potentially face ... are either already resistant or rapidly acquiring resistance to ...

A groundbreaking cannabinoid-based antimicrobial, Silvanex, fights drug-resistant infections with a synergy of silver, CBC and CBG.

Now, biologists at The University of Manchester have shown that chemicals called azoles - the active agent in many antifungal drugs - kill the TB bacteria, and could be effective in tackling the ...

An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic ... used the known mode of action of fluorocytosine on A. fumigatus as the ...

One thing is certain: The threat of fungal infections is growing, as fungi either evolve ways to evade drugs that once worked, or pop up in places they haven’t been seen before. “We have limited ...

Secondary objectives included assessing the frequency of changes in antifungal therapy due to infusion-related reactions involving amphotericin B formulations, evaluating mycological cure rates in ...

Table 1 Selected companies and their antibacterial and antifungal programs ... in the concentration of the drug target—thus eliminating it as a site of action; changes in molecule biosynthesis ...