Enter the anti-CRISPR protein AcrVIB1, a promising inhibitor whose exact function has remained a mystery—until now. A research team from the Helmholtz Institute for RNA-based Infection Research ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into ...

In bacteriophage genomes, researchers find three anti-CRISPR proteins that naturally inhibit CRISPR-Cas9 in one bacterial species and can do the same in human cells. Notably, the work is “going ...

under the assumption that the genome likely contained an inhibitor to prevent CRISPR from cutting that target in the bacterium’s own genome. Indeed, Rauch and colleagues uncovered several anti-CRISPRs ...

The scientists found three proteins that block CRISPR, known as anti-CRISPRs. U of T Faculty of Medicine's Alan Davidson, a professor of molecular genetics and biochemistry, and Karen Maxwell, an ...

Enter the anti-CRISPR protein AcrVIB1, a promising inhibitor whose exact function has remained a mystery—until now. A research team from the Helmholtz Institute for RNA-based Infection Research (HIRI) ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

Targeted CRISPR lipid nanoparticles eliminated 50% of tumors in mice with head and neck cancer.

The ongoing major projects in the laboratory focus on the structural biology of CRISPR-Cas surveillance complexes and their suppression by anti-CRISPR proteins (in collaboration with Luciano ...

Current research in the Doudna lab focuses on discovering and determining the mechanisms of novel CRISPR-Cas and associated proteins; developing genome editing tools for use in vitro, in plants, and ...