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A research team led by Professor Takuya Yamamoto (Department of Life Science Frontiers) and Professor Yasuhiro Yamada at the University of Tokyo has developed a novel in vivo system that reveals how ...
Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme ...
The exocyst in a conserved octameric complex that mediates the tethering of secretory vesicles for exocytosis in eukaryotes. In fission yeast cells, the exocyst is necessary for cell division, where ...
Porosome Therapeutics, Inc. is a Boston-based biopharmaceutical company utilizing the breakthrough discovery of the porosome, the cell’s secretory machinery, and novel technologies to identify and ...
Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? Using intestinal organoids, scientists identified a ...
Figure 1. Secretory autophagy is at the crossroads of endo‐ and exocytosis Secretory autophagy (3, 5) overlaps with endo/exocytotic pathways (1) and lysosomal exocytosis (2) and the key overlapping ...
The release of peptide hormones or neurotransmitters from neuroendocrine cells is essential for the co-ordination of diverse physiological events. Secretory vesicles derived from the trans-Golgi ...
In secretory cells with a dedicated role in regulated exocytosis, this leads to exposure of the secretory granules to lysosomal enzymes and uncontrolled regulated exocytosis.
Secretory cells respond to hypertonic stress by cell shrinking, which causes a reduction in exocytosis activity and the amount of signaling molecules released from single exocytosis events. These ...
In neuroendocrine cells, exocytosis involves the fusion of secretory vesicles, carrying signaling molecules, with the plasma membrane through the coordinated interplay of proteins, lipids, and small ...
In neurons and neuroendocrine cells, release of neurotransmitters, neuropeptides, and hormones occurs through calcium-regulated exocytosis at the plasma membrane. To allow recycling of secretory ...
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