In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is commonly known to be responsible for protein trafficking and secretion. In ...

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New research details the subcellular structures in neurons that enable signals to be transmitted from where they are received at specific sites on dendrites to the decision-making cell body located ...

Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the endoplasmic reticulum.

Before joining Raw Story, Brad Reed spent eight years writing about technology at BGR.com and Network World. Prior to that, he wrote freelance stories for political publications such as AlterNet ...

Nat Clin Pract Endocrinol Metab. 2006;2(6):298-299. Clearly, dopamine agonists should not be withdrawn too early, and certainly not before completion of 12 months' treatment. Until more is known ...

Neurological diseases are highly heterogeneous; however, they share a common pathogenesis, that is, the aberrant accumulation of misfolded/unfolded proteins within the endoplasmic reticulum (ER).

The endoplasmic reticulum (ER), extending throughout the cytoplasm of eukaryotic cells, is a central organelle involved in lipid metabolism, Ca 2+ homeostasis, and synthesis and folding of secretory ...

Stem cell differentiation involves a global increase in protein synthesis to meet the demands of specialized cell types. However, the molecular mechanisms underlying this translational burst and the ...