Conclusion: Q-T interval prolongation and TdP associated with the use of methadone are potentially fatal adverse effects. A thorough patient history and ECG monitoring are essential for patients ...

Upon review of this body and the described ECG findings, certain common patterns ... cocaine use and AV conduction as assessed by PR interval length appears to be somewhat contradictory.

Likewise class 3 drugs (bretylium, amiodarone) also prolong the QT interval and may predispose to arrhythmias. The use of β blockers may further reduce myocardial contractility and although reported ...