Findings suggest that elevated plasma levels of ADM impair insulin receptor function in endothelial cells, leading to reduced vascular insulin delivery and systemic insulin resistance. Obesity is ...

Flavonoids show promise in treating type 2 diabetes mellitus by targeting the enteroendocrine system and regulating key gut ...

Glucose (1.75 g/kg to a maximum of 75 g) was administered po and samples obtained for blood glucose and plasma insulin (IRI) at 0, 30, 60, 120 and 180 min. We studied 16 of the pts during the ...

Plasma glucose was measured by enzymatic hexokinase photometric assay (Konelab Systems reagents; Thermo Fischer Scientific, Vantaa, Finland). Insulin was determined by immunoassay (ADVIA Centaur ...

Second, we found that metabolic concentrations of plasma LPS are a sufficient molecular ... Finally, the LPS receptor CD14, by controlling insulin sensitivity, sets the threshold at which ...

Biomea Fusion (BMEA) announced the presentation of preclinical and clinical data from studies assessing icovamenib at the ...

Circulating insulin binds to insulin receptors on blood vessel endothelium, leading to activation of endothelial nitric oxide synthase (eNOS), NO-mediated vasodilation and increased perfusion of ...