These alterations increase tension on the nuclear envelope of daughter cells, triggering the activation of mechanosensors mTORC2 and ATR, which induces a p53- and p21-dependent cell cycle arrest.

Additionally, ferulic acid upregulated tumor suppressor proteins p53 and p21, which are pivotal in initiating apoptosis. Dr. Xi Chen, one of the authors of the study, emphasized the significance ...

Although it mediates p53-driven repression through the canonical p53-p21-Rb axis, the potential for p53 to directly regulate DREAM targets independently of its transcriptional activity has not been ...

Gokongwei-led Robinsons Land Corporation showcased resilience and strategic growth in 2024, with a 10 percent increase in net attributable income to P13.21 billion.

Recently, significant pathways involved in regulating senescence have been delineated, including p53/p21 and p16INK4a/Rb, along with the senescence-associated secretory phenotype (SASP), which fosters ...

They assessed senescence markers like SA-β-galactosidase activity, cell proliferation rates, and expression of cell cycle inhibitors including p53 and p21. To determine AP2A1’s role ...

Ubiquitin-specific protease 7 (USP7) is involved in DNA repair and cell cycle progression and, due to its control over the ubiquitination of key proteins, may impact oncogenes like MDM2 and c-Myc, as ...

Cell-cycle mediators (p21, IAP1 and 2 and XIAP ... Other markers involved in cell propagation and metastasis examined to date are p53, vascular cell adhesion molecule (VCAM) and COX-2.