Since p53 regulates many other target genes in addition to p21 with diverse cellular outcomes, we next sought to determine whether there were effects on the expression of other target genes. Our ...

Protein changes in p21, p53, cyclin A1, cyclin A2, and cyclin E1 were consistent with the mRNA changes (P < 0.01). Additionally, the HIF-1α level of the HG + Rot group was significantly higher than ...

If the glucose deprivation may result in the observed overall low mRNA levels of CDK1 and the therefore low cell ... notably the upregulation of p21 and the downregulation of CDK1, highlights the ...

The findings, in mouse models and isolated human brain tissue, were published in Nature Materials in a paper titled "Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the ...

Shares of biotechnology company Moderna (NASDAQ:MRNA) jumped 11.8% in the morning session after it continued to build on the 3% gain from Friday when it reported fourth-quarter 2024 financial results.

Researchers at the Icahn School of Medicine at Mount Sinai say they have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection ...

MANILA, Philippines — Taipan Lucio Tan-led Philippine National Bank (PNB) recorded an 18-percent climb in its earnings last year to P21.2 billion on growth in its core businesses, particularly ...

Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials , 2025; DOI: 10.1038/s41563-024-02114-5 Cite This Page : ...

Scientists at the Icahn School of Medicine at Mount Sinai have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge ...