Nanoparticles of a certain size range, with minor macrophage uptake and prolonged blood half-life time can passively accumulate on tumors, taking advantage of the progressive permeation through ...

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

Modifying the physical characteristics of microscopic biomaterials to interact seamlessly with the body's tissues could ...

which could be beneficial in cancer therapy by targeting tumor-associated macrophages[5]. Overall, the research indicates a growing interest in the green synthesis of selenium nanoparticles and ...

Modifying the physical characteristics of microscopic biomaterials to interact seamlessly with the body's tissues could unlock safer and more effective cancer treatments, according to Virginia Tech ...

Effect of nanoparticle shape on biodistribution & macrophage uptake The rate of internalization of a nonspherical nanoparticle depends on its angular orientation relative to the cell membrane.

Modifying the physical characteristics of microscopic biomaterials to interact seamlessly with the body's tissues could ...

Attribution (BY): Credit must be given to the creator. Macrophages are the primary cells responsible for nanoparticle processing and mediating host immunological biological outcomes. Their cellular ...

and evaluating the therapeutic impact of simultaneously targeting both macrophages and fibroblasts. Multidisciplinary approaches combining advanced techniques like spatial transcriptomics, ...

This new nanoparticle offers a way to address the problem at its root by stabilizing and reducing the plaques. The research focuses on a type of immune cell called macrophages, which play a ...

2019). In 2021, Kang’s team developed an innovative approach to cancer therapy by using nanoparticle carriers to transfect genes encoding CAR and IFN-γ into macrophages, creating MPEI/pCAR-IFN-γ. When ...