Increased total tau and phosphorylated tau species (Thr181, Ser199, Thr231) in the amygdala and hippocampus starting at three months. Spatial memory deficits starting at five months by the Morris ...

Given the vast range of possible interactions in peptide design, it may be feasible to tailor peptides for specific drugs, extending their applicability beyond cancer treatments. "This ...

Approval is based on data from the Phase III CodeBreaK 300 trial, which demonstrated that treatment with Lumakras and Vectibix significantly improved progression-free survival in patients with KRAS ...

The AI design features unusual and efficient, circuitry patterns. Credit: Emir Ali Karahan, Princeton University. When chips are usually designed, scientists and engineers work with patterns and ...

This repeated growth didn’t have much effect on the patients until the gene mutated in size to more than 150 repeats. At this point, other genes that are normally turned off in SPNs begin to ...

This new option validates our combination approach to improve outcomes for patients living with advanced KRAS G12C-mutated metastatic colorectal cancer." The CodeBreaK 300 clinical trial compared ...

The combination treatment specifically targets KRAS-mutated metastatic colorectal cancer (CRC) to improve progression-free survival. The approval was based on results from CodeBreaK 300 ...