Exposure to a common fungal molecule can reprogram immune cells in the lungs, causing them to overreact to infection-like ...

Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

Mast cells can also influence many aspects of the biology of immune cells, including granulocytes, monocytes/macrophages, dendritic cells (DCs), T cells, B cells, natural killer (NK) cells and NKT ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

One analyst described Cogent’s data as a “home run scenario” for bezuclastinib, which the company is positioning as a ...

Shares of Cogent Biosciences were higher after the company disclosed what it called positive top-line results from a recent trial of its treatment for certain types of mastocytosis, a rare disorder in ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer ...

Urinary mast cell mediators, specifically 2,3-BPG, NMH, and LTE4, were quantified using liquid chromatography-tandem mass spectrometry and normalized to creatinine (Cr) levels. Statistical analyses ...

Monoclonal mast cell disorders encompass mast cell-related conditions in which investigations provide evidence of clonality. In most cases, this evidence is based on the detection of an activating ...

Objective Checkpoint immunotherapy unleashes T-cell control of tumours but is suppressed by immunosuppressive myeloid cells. The transmembrane protein MS4A4A is selectively highly expressed in ...

SCF can be produced by stimulated fibroblasts and endothelial cells. 5152 Recently, bone marrow macrophages were demonstrated to produce SCF. 53 It seemed reasonable to hypothesize that ...