eLife16d
STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer
All cell lines used in this study, including HCC1806, HCC1937, and HEK293T cells, were purchased from ATCC (American Type Culture Collection ... The DNA fragments HIF1α and GRHL3 were amplified from ...
The EMBO Journal5d
MHC-I upregulation by macbecin II in the solid tumors potentiates the effect of active immunotherapy
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. We aimed to restore MHC-I expression on the ...
C&EN13d
Characterization of RufT Thioesterase Domain Reveals Insights into Rufomycin Cyclization and the Biosynthetic Origin of Rufomyazine
Department of Chemistry, Faculty of Natural, Mathematical and Engineering Sciences, King’s College London, Britannia House, 7 Trinity Street, London SE1 1DB, U.K. Department of Chemistry, Faculty of ...
Frontiers15d
Compressive stress drives adhesion-dependent unjamming transitions in breast cancer cell migration
As compressive stress is applied to normal breast epithelial cells (MCF10A) and metastatic breast cancer cells (4T1), MCF10A cells are rendered immobile, while 4T1 cells become fluid-like and migrate ...
eLife15d
Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction
This fundamental study provides compelling evidence that TRPV4 plays a crucial role in mechanical sensing during cancer cell transition from non-invasive to invasive states, and offers novel insights ...