One of the principal observations by Rothman's group was that the vesicles that formed in the Golgi moved cargo proteins between cisternae from the cis face to the trans face. These observations ...

In our study we identified a dynamic Golgi-independent tubular network that transports ER-derived cargos and interacts with pre-existing Golgi to mature into new pre-Golgi cisternae in a lipid ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Dynamic changes in the arrangement of ...

Gaucher disease (GD) is an inherited disorder caused by recessive mutations in the GBA1 gene that encodes the lysosomal enzyme β-glucocerebrosidase (β-GC). β-GC hydrolyzes glucosylceramide (GluCer) ...

1 Department of Biological Sciences, East Tennessee State University, Johnson City, TN, United States 2 Max Planck Institute for the Physics of Complex Systems, Dresden, Germany Proinsulin misfolding ...