The rate-limiting proton transfer (PT) event in the site-specific mutant N67L of human carbonic anhydrase II (HCA II) has been examined by kinetic, X-ray, and simulation approaches. The X-ray ...

This paper examines the functional mechanism of thioxolone, a compound recently identified as a weak inhibitor of human carbonic anhydrase II by Iyer et al. (2006) J. Biomol. Screening 11, 782−791.

A team of researchers, led by Professor Chae Un Kim from the Department of Physics at UNIST, has successfully tracked the ...

By integrating an ultraviolet (UV) photolysis technique with temperature-controlled X-ray crystallography, we track the catalytic pathway of carbonic anhydrase II (CAII) at 1.2 Å resolution. This ...

Abstract Water plays an essential role in enzyme structure, stability, and the substantial rate enhancement of enzyme catalysis. However, direct ...

A Novel Thiazole-Sulfonamide Hybrid Molecule as a promising Dual Tubulin/Carbonic Anhydrase IX Inhibitor with Anticancer Activity ... the downregulation of Bcl-2, and the significant activation of ...

The US Department of Energy (DOE) is canceling billions of dollars in awards intended to reduce industrial carbon emissions, and it is proposing major cuts to programs focused on decarbonization ...