The Bills beat the Patriots 24-21 thanks to the performance from starting running back James Cook along with timely plays made by the defense. Cook ran the ball 11 times for 100 yards and one touchdown while also catching three passes for 26 yards and another touchdown, showing his ability to affect the game on the ground and through the air.

Josh Allen doesn't have to do it all, and may be hard-pressed to top 4,000 yards passing for a fifth consecutive season. And that’s not a bad thing.

The Buffalo Bills won a nail-biter against the New England Patriots, 24-21, in Week 16 action. The Bills, a massive 14.5-point favorite entering the game, struggled mightily to dominate their lowly divisional rivals.

In Sunday’s 24-21 victory over the New England Patriots, the Bills trotted out a new personnel grouping for the first time this season.

A whole lot of running back James Cook and takeaways by the defense helped the Buffalo Bills erase an early 14-point deficit Sunday against the New England Patriots.

James Cook will lead the Buffalo Bills into their game versus the New England Patriots at Highmark Stadium on Sunday at 4:25 p.m. ET.The Patriots have been sputtering offensively, ranking

Buffalo Bills' running back James Cook breaks away from the New England Patriots' defense on an explosive 46-yard touchdown run. Dallas Cowboys cornerback DaRon Bland yanks a game-sealing takeaway from Tampa Bay Buccaneers running back Rachaad White's grasp.

Josh Allen may be hard-pressed to top 4,000 yards passing for a fifth consecutive season. And that’s not a bad thing. As much as the five-time defending AFC East champion

The New England Patriots dusted off a "vintage" scheme against the Buffalo Bills in Week 16 to improve a struggling defense.

NFL Week 16 was chock-full of exciting finishes, with the majority of games decided by one score. Big-time players made big-time plays. And since they did, they’re getting a big-time honor: Game Balls from Pro Football Network.