The Giants are on the verge of their worst season in 50 years. Will Big Blue go winless at home? Our Week 17 staff predictions vs. Colts.

Heading into Week 16, the Colts are on the outside of the AFC playoff field. Indianapolis sits in the No. 8 seed spot in the standings, but 2.5 games back of the Chargers and Broncos, who have nine wins.

Pete Prisco is picking the Colts to win by a touchdown. While others think that last week’s loss will rollover into this game against Tennessee, Prisco thinks the opposite, mentioning that the Colts defense did a lot of good things last week, resulting in a bounce-back win.

Get the latest Titans vs. Colts predictions ahead of Sunday's AFC south clash. Free NFL picks and predictions for December 22.

Johnson: "Here’s what you need to know entering this Week 17 matchup, the New York Giants have allowed 151.3 rushing yards per game, 4.9 yards per carry and 15 rushing touchdowns in the last 11 games. The Indianapolis Colts ran the football to their last win over the Tennessee Titans, same formula here."

The NFL regular season has just two weeks left as plenty of teams are in must-win spots, while others could begin resting players ahead of the playoffs. Unfortunately, we lost our Week 16 parlay, which was the first time in five weeks we lost.