Most proteins in blood are measured outside their functional and cellular context. Machine learning was used to integrate ...

Basic research, often termed fundamental, frontier, blue-sky, curiosity-driven—or even useless—is the pursuit of knowledge ...

Several recent studies show that the E3 ligase RNF114 recognises a hybrid ADP-ribose-ubiquitin modification on substrate ...

Understanding temporal dynamics in tissue biology is key to linking transcriptomic snapshots to physiological function.

This cover highlights the article Programmed cell revival from imminent cell death enhances tissue repair and regeneration by ...

Paxillin, long known as a cytoplasmic scaffold protein involved in cell adhesion and migration, emerges in a new role as a ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study identifies a pathway for oxidation ...

Current understandings on cell motility and directionality rely heavily on accumulated investigations of the adhesion–actin cytoskeleton–actomyosin contractility cycles, while microtubules have been ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. It remained unknown how the ubiquitin ligase ...

Under normal conditions, SR proteins are hyperphosphorylated at their intrinsically disordered regions containing SR and SP dipeptides. Upon heat shock, SR proteins are rapidly dephosphorylated.

(A) The V2 vasopressin receptor (V2R) contains in its carboxyl‐terminal tail region clusters of Ser/Thr potential GRK phosphorylation sites (phosphocodes, green key). V2 activation stimulates Erk ...

As well as classical hierarchical differentiation and regulated cell turnover from dedicated stem cell populations, it is now clear that differentiated cells in adult tissues are capable of ...